Negative regulation of proteasomal protein catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of proteasomal protein catabolic process pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 52 member genes.

The strongest signal is observed in kidney chromophobe (KICH), where higher Negative regulation of proteasomal protein catabolic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and ESCA, show the opposite pattern, with higher activity associated with better survival.

KICH, UVM, and SCLC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Quartile	II,III,IV	0.223	0.888	<.001	76	view →
UVM	DFS	Quartile	III,IV	0.129	0.830	<.001	63	view →
SCLC	DFS	Tertile	III,IV	0.811	0.240	<.001	42	view →
MESO	OS	Tertile	III,IV	0.052	0.569	.014	36	view →
ESCA	DFS	Quartile	III,IV	0.609	0.228	.005	24	view →
KIRP	OS	Quartile	II,III,IV	0.265	0.710	.005	23	view →
HNSC	DFS	Median	II,III,IV	0.793	0.576	.003	14	view →
SKCM	OS	Tertile	All	0.334	0.293	.014	14	view →
LUAD	OS	Median	All	0.403	0.293	.019	14	view →
THCA	OS	Tertile	All	0.873	0.967	.026	12	view →
READ	DFS	Tertile	II,III,IV	0.931	0.506	.012	11	view →
BLCA	OS	Quartile	III,IV	0.689	0.383	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:1901799–KICH (DFS)

Open the KICH breakdown →