Negative regulation of cell proliferation involved in kidney development

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell proliferation involved in kidney development pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCKAP1, KCNMB4, and SUPV3L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NCKAP1 grouped by Negative regulation of cell proliferation involved in kidney development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NCKAP1 →	-0.326	-0.310	<.001	<.001	3	4
BONE	KCNMB4 →	+0.300	+0.411	.001	<.001	3	3
BLOOD_Leukemia	SUPV3L1 →	+0.185	+0.181	.009	<.001	3	3
SOFT_TISSUE	CYC1 →	+0.278	+0.261	.006	.002	3	3
KIDNEY	ATP5F1E →	+0.221	+0.249	.006	.007	3	3
KIDNEY	GALM →	+0.237	+0.208	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NCKAP1 by Negative regulation of cell proliferation involved in kidney development activity — SOFT_TISSUE

Explore this box plot interactively →