Negative regulation of cell proliferation involved in kidney development

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of cell proliferation involved in kidney development pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Negative regulation of cell proliferation involved in kidney development pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and LGG, show the opposite pattern, with higher activity associated with better survival.

UVM, LGG, and STAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.726	0.448	.002	70	view →
LGG	DFS	Median	All	0.822	0.662	<.001	51	view →
STAD	DFS	Median	IV	0.670	0.286	.003	30	view →
UCEC	DFS	Median	IV	0.823	0.555	.024	28	view →
KIRP	DFS	Quartile	II,III,IV	0.193	1.000	.013	21	view →
LUAD	DFS	Median	IV	0.666	0.978	.015	19	view →
READ	OS	Median	All	0.802	0.993	.009	18	view →
HNSC	DFS	Median	All	0.761	0.658	.006	18	view →
LIHC	OS	Median	III,IV	0.201	0.620	.002	18	view →
BLCA	OS	Median	All	0.488	0.372	.021	16	view →
SKCM	DFS	Quartile	III,IV	0.821	0.520	.016	13	view →
ACC	OS	Tertile	III,IV	1.000	0.453	.011	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:1901723–UVM (DFS)

Open the UVM breakdown →