Alpha-amino acid catabolic process

Across TCGA patient cohorts, RNA activity of the Alpha-amino acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSE1L, ZBTB16, and SMC4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alpha-amino acid catabolic process activity versus CSE1L in LSCC (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CSE1L →	-0.576	-0.205	<.001	<.001	3	7
LUAD	ZBTB16 →	+1.425	+0.133	<.001	.009	3	6
GBM	SMC4 →	-0.706	-0.205	<.001	<.001	3	6
LSCC	RPS17 →	-0.396	-0.145	.006	.009	3	6
LSCC	PDK4 →	+1.335	+0.188	<.001	<.001	3	6
HNSC	IRAG2 →	+0.721	+0.183	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901606 vs CSE1L — LSCC

Explore this scatter interactively →