Alpha-amino acid catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Alpha-amino acid catabolic process pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 92 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Alpha-amino acid catabolic process pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and LIHC, show the opposite pattern, with higher activity associated with better survival.

KIRP, ESCA, and LIHC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.891	0.216	<.001	59	view →
ESCA	OS	Median	All	0.563	1.000	.003	53	view →
LIHC	OS	Tertile	All	0.791	0.602	<.001	51	view →
THYM	OS	Quartile	II,III,IV	0.772	1.000	.001	47	view →
HNSC	DFS	Quartile	IV	0.766	0.334	.001	46	view →
DLBC	OS	Tertile	II,III,IV	0.279	1.000	.003	32	view →
PAAD	OS	Tertile	All	0.743	0.437	.001	28	view →
SCLC	DFS	Median	All	0.740	0.533	.007	27	view →
CHOL	OS	Tertile	II,III,IV	0.088	0.780	<.001	24	view →
READ	OS	Tertile	IV	0.441	0.933	<.001	20	view →
GBM	DFS	Quartile	All	0.167	0.329	.002	19	view →
LUAD	OS	Median	II,III,IV	0.664	0.458	.024	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:1901606–KIRP (DFS)

Open the KIRP breakdown →