Alpha-amino acid catabolic process

Across TCGA cell cohorts, RNA activity of the Alpha-amino acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM47E, ERBB3, and MCCC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alpha-amino acid catabolic process activity versus FAM47E in LARGE_INTESTINE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM47E →	+1.257	+0.243	.003	.003	3	7
OVARY	ERBB3 →	+1.844	+0.203	.005	<.001	3	7
BLOOD_Leukemia	MCCC2 →	+0.701	+0.208	.001	<.001	3	6
URINARY_TRACT	JMY →	+0.535	+0.242	.006	.006	3	6
URINARY_TRACT	FRAT2 →	+1.002	+0.253	.001	.003	3	6
BREAST	ESRP2 →	+2.449	+0.247	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901606 vs FAM47E — LARGE_INTESTINE

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