family with sequence similarity 47 member EGenealiases: []
Q-omics provides the consensus-scored FAM47E profile across patient tissues and cancer cell-line models. FAM47E expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, FAM47E is differentially expressed in 12, with the highest sampling consensus in KICH. Additionally, FAM47E RNA expression shows 18,886 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, KICH, and UVM as cancer lineages where FAM47E shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM47E — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM47E survival associations across molecular data types. FAM47E RNA expression shows survival associations in the most cancer types (16). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM47E RNA expression–survival associations across cancer types. High FAM47E expression shows unfavorable associations in UVM and CHOL, but favorable associations in KIRC, UCEC, KIRP and LUAD. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for FAM47E RNA expression.
This table summarizes FAM47E tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for FAM47E. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM47E shows lower tumor expression in KICH, KIRC, LUAD, LUSC and BRCA and higher tumor expression in LIHC. The KICH box plot shows higher FAM47E RNA expression in normal versus tumor tissue (log2 FC = −1.060, t-test p < 0.001).
This table shows molecular features associated with FAM47E in patient tissues and cancer cell lines. In patient samples, FAM47E shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, FAM47E RNA and mutation anchors are most strongly linked to RNA-expression features, especially in URINARY_TRACT, while CRISPR and shRNA rows add functional-dependency signals in OVARY and BREAST.
