Alpha-amino acid metabolic process

Across TCGA patient cohorts, RNA activity of the Alpha-amino acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GPT2, TBC1D2B, and AIFM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alpha-amino acid metabolic process activity versus GPT2 in LUAD (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GPT2 →	+0.532	+0.022	<.001	<.001	3	7
LUAD	TBC1D2B →	-0.229	-0.039	<.001	<.001	3	6
OV	AIFM1 →	+0.621	+0.023	<.001	.001	3	6
GBM	NR2C2 →	-0.202	-0.025	<.001	<.001	3	6
LUAD	GCSH →	+0.380	+0.028	.001	<.001	3	6
GBM	ATPAF1 →	+0.327	+0.026	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901605 vs GPT2 — LUAD

Explore this scatter interactively →