Alpha-amino acid metabolic process

Across TCGA patient cohorts, RNA activity of the Alpha-amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF326, BRD2, and MYO19, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alpha-amino acid metabolic process activity versus ZNF326 in LSCC (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZNF326 →	-0.491	-0.136	<.001	.001	3	6
COAD	BRD2 →	-0.486	-0.164	.003	.006	3	6
LSCC	MYO19 →	-0.609	-0.213	<.001	<.001	3	6
LSCC	BCL7A →	-0.711	-0.180	<.001	<.001	3	6
LSCC	PANK3 →	-0.627	-0.196	<.001	<.001	3	6
LSCC	PRPF38B →	-0.364	-0.134	<.001	.008	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901605 vs ZNF326 — LSCC

Explore this scatter interactively →