Fatty acid derivative catabolic process

Across TCGA patient cohorts, RNA activity of the Fatty acid derivative catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUDT8, COQ9, and ATP5F1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid derivative catabolic process activity versus NUDT8 in BRCA (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NUDT8 →	+0.431	+0.038	<.001	<.001	3	6
COAD	COQ9 →	+0.414	+0.041	.001	.002	3	6
HNSC	ATP5F1B →	+0.273	+0.065	<.001	<.001	3	5
HNSC	ATP5F1C →	+0.271	+0.049	<.001	<.001	3	5
BRCA	ETFB →	+0.335	+0.033	<.001	<.001	3	5
COAD	GSTK1 →	+0.366	+0.034	.003	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901569 vs NUDT8 — BRCA

Explore this scatter interactively →