Fatty acid derivative catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Fatty acid derivative catabolic process pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 18 member genes.

The strongest signal is observed in small cell lung cancer (SCLC), where higher Fatty acid derivative catabolic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and PAAD, show the opposite pattern, with higher activity associated with better survival.

SCLC, HNSC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	II,III,IV	0.230	0.793	.003	32	view →
HNSC	DFS	Tertile	II,III,IV	0.242	0.476	.015	27	view →
KIRC	DFS	Quartile	All	0.936	0.841	.005	22	view →
PAAD	OS	Tertile	II,III,IV	0.849	0.472	.005	18	view →
LUAD	DFS	Quartile	II,III,IV	0.458	0.225	.023	18	view →
BLCA	DFS	Quartile	IV	0.685	0.266	.005	17	view →
KIRP	OS	Median	All	0.973	0.819	.019	16	view →
UVM	OS	Tertile	All	0.447	0.853	.026	14	view →
ESCA	OS	Median	III,IV	0.732	0.462	.013	12	view →
UCEC	OS	Quartile	II,III,IV	0.690	0.838	.027	10	view →
THCA	DFS	Tertile	IV	0.344	0.755	.012	10	view →
GBM	DFS	Median	All	0.154	0.247	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:1901569–SCLC (DFS)

Open the SCLC breakdown →