Positive regulation of potassium ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of potassium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL8, NAP1L3, and THAP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of potassium ion transmembrane transport activity versus METTL8 in CNS (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	METTL8 →	-0.868	-0.277	.002	.003	3	6
SKIN	NAP1L3 →	-0.944	-0.235	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	THAP1 →	-0.559	-0.245	.003	.006	3	5
CNS	ATP1A1 →	+1.006	+0.195	.003	.009	3	4
OVARY	ACTR2 →	-0.588	-0.289	.007	.009	3	4
OVARY	TNKS1BP1 →	+0.634	+0.290	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901381 vs METTL8 — CNS

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