Positive regulation of potassium ion transmembrane transport

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of potassium ion transmembrane transport pathway differs between tumor and matched normal tissue in 9 of the 18 cancer types tested.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as UCEC and BRCA, show the opposite pattern, with lower activity in tumor tissue.

KIRC, KICH, and LIHC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRC	All	II,III,IV	+0.031	<.001	9	view →
KICH	All	II,III,IV	+0.035	<.001	7	view →
LIHC	All	II,III,IV	+0.034	<.001	7	view →
UCEC	All	All	−0.051	<.001	6	view →
BRCA	All	All	−0.035	<.001	6	view →
COAD	Male	II,III,IV	−0.030	<.001	6	view →
CHOL	Male	All	+0.079	<.001	5	view →
READ	All	All	−0.035	.004	3	view →
BLCA	Male	IV	−0.032	.019	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 9 strongest of 9 lineages.

GO:1901381–KIRC

Open the KIRC breakdown →