Regulation of potassium ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Regulation of potassium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R13L, SLC15A3, and WDR12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of potassium ion transmembrane transport activity versus PPP1R13L in LIVER (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PPP1R13L →	+2.750	+0.367	.001	.001	3	6
URINARY_TRACT	SLC15A3 →	+2.335	+0.295	<.001	.001	3	6
PANCREAS	WDR12 →	-0.491	-0.221	.003	.003	3	6
LIVER	UMPS →	-1.086	-0.425	.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	RIDA →	-1.369	-0.296	<.001	.007	3	5
LARGE_INTESTINE	CAV2 →	+2.638	+0.203	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901379 vs PPP1R13L — LIVER

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