Response to rapamycin

Across TCGA patient cohorts, RNA activity of the Response to rapamycin pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLK, LIPA, and SLF2, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to rapamycin activity versus POLK in UVM (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	POLK →	+1.066	+0.056	<.001	<.001	3	32
ACC	LIPA →	+1.692	+0.064	<.001	<.001	3	31
CHOL	SLF2 →	+0.979	+0.084	<.001	.001	3	31
CHOL	CEP350 →	+1.139	+0.098	.004	.003	2	32
UVM	NEK1 →	+0.988	+0.058	<.001	<.001	3	31
UVM	SECISBP2L →	+1.308	+0.059	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901355 vs POLK — UVM

Explore this scatter interactively →