Response to rapamycin

Across TCGA patient cohorts, RNA activity of the Response to rapamycin pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASH2L, TRIM22_S384, and HLA-F, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to rapamycin activity versus ASH2L in HNSC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ASH2L →	+0.213	+0.073	.004	.007	3	5
HNSC	TRIM22_S384 →	-0.847	-0.056	.004	.002	2	6
BRCA	HLA-F →	-0.463	-0.036	<.001	<.001	3	5
PDAC	BAK1 →	-0.443	-0.043	.003	<.001	3	5
BRCA	FMNL1_S184 →	-0.800	-0.048	<.001	<.001	3	5
HNSC	RAB9A →	-0.280	-0.088	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901355 vs ASH2L — HNSC

Explore this scatter interactively →