Response to rapamycin

Across TCGA patient cohorts, RNA activity of the Response to rapamycin pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRAG1, TINAGL1, and ARHGAP6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to rapamycin activity versus IRAG1 in UCEC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRAG1 →	-0.688	-0.147	.005	.004	3	7
CCRCC	TINAGL1 →	-0.878	-0.216	<.001	<.001	3	6
LUAD	ARHGAP6 →	-0.481	-0.204	<.001	<.001	3	6
CCRCC	CSDC2 →	-1.483	-0.201	<.001	<.001	3	5
CCRCC	ESAM →	-0.649	-0.161	.008	.006	3	5
CCRCC	ERG →	-0.529	-0.127	.009	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901355 vs IRAG1 — UCEC

Explore this scatter interactively →