Response to rapamycin

Across TCGA cell cohorts, RNA activity of the Response to rapamycin pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL3, RPL4, and EEF1A1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to rapamycin activity versus RPL3 in PANCREAS (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RPL3 →	+0.784	+0.260	<.001	<.001	3	9
LUNG_SCLC	RPL4 →	+0.857	+0.122	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	EEF1A1 →	+0.882	+0.194	.002	.005	3	8
UPPER_AERODIGESTIVE_TRACT	EIF4B →	+1.101	+0.243	<.001	<.001	3	8
LARGE_INTESTINE	RPS9 →	+0.521	+0.172	<.001	<.001	3	8
BONE	FBL →	+1.195	+0.235	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901355 vs RPL3 — PANCREAS

Explore this scatter interactively →