Regulation of odontoblast differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of odontoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HK2P1, HK2, and SERPINE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of odontoblast differentiation activity versus HK2P1 in OV (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HK2P1 →	+0.735	+0.343	<.001	.001	3	4
GBM	HK2 →	+0.694	+0.316	.001	.008	3	4
CCRCC	SERPINE1 →	+1.586	+0.423	<.001	.001	3	4
CCRCC	NMRAL2P →	+1.040	+0.322	.002	.005	3	4
BRCA	PELATON →	+0.676	+0.213	.001	.003	3	4
CCRCC	PI3 →	+1.199	+0.272	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901329 vs HK2P1 — OV

Explore this scatter interactively →