Regulation of odontoblast differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of odontoblast differentiation pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Regulation of odontoblast differentiation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and ESCA, show the opposite pattern, with higher activity associated with better survival.

ACC, KIRP, and STAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.410	0.746	<.001	141	view →
KIRP	OS	Quartile	All	0.864	0.990	<.001	123	view →
STAD	DFS	Tertile	All	0.279	0.493	<.001	101	view →
BLCA	DFS	Quartile	III,IV	0.414	0.605	.001	60	view →
OV	OS	Median	III,IV	0.781	0.880	.005	58	view →
LGG	DFS	Median	All	0.619	0.841	<.001	54	view →
THCA	OS	Tertile	II,III,IV	0.690	0.987	.002	51	view →
KIRC	DFS	Tertile	All	0.515	0.693	<.001	49	view →
UCEC	OS	Quartile	All	0.895	0.974	.001	30	view →
PAAD	DFS	Tertile	II,III,IV	0.334	0.555	.011	26	view →
LIHC	DFS	Quartile	All	0.290	0.525	.001	22	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:1901329–ACC (DFS)

Open the ACC breakdown →