Nucleoside phosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Nucleoside phosphate biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UQCRC2, MRPL37, and UQCRQ, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UQCRC2 grouped by Nucleoside phosphate biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	UQCRC2 →	-0.447	-0.210	<.001	<.001	3	8
LUNG_NSCLC_LUAD	MRPL37 →	-0.267	-0.134	<.001	.003	3	6
STOMACH	UQCRQ →	-0.465	-0.209	<.001	<.001	3	6
LUNG_SCLC	ATP5PO →	-0.315	-0.207	.004	.001	2	7
BREAST	NDUFB5 →	-0.286	-0.179	<.001	<.001	3	6
BREAST	ATP5F1B →	-0.426	-0.176	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UQCRC2 by Nucleoside phosphate biosynthetic process activity — BREAST

Explore this box plot interactively →