Carbohydrate derivative transport

Across TCGA patient cohorts, RNA activity of the Carbohydrate derivative transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM7A-DT, MR1, and CXCR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate derivative transport activity versus KDM7A-DT in UCEC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KDM7A-DT →	+0.903	+0.283	.002	.006	3	4
OV	MR1 →	+0.421	+0.154	.005	<.001	3	4
PDAC	CXCR1 →	+1.044	+0.495	<.001	<.001	3	4
CCRCC	CFAP161 →	-0.335	-0.169	.006	.005	3	3
CCRCC	FMNL3 →	-0.357	-0.192	.009	.006	2	4
PDAC	ZNF649 →	-0.431	-0.420	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901264 vs KDM7A-DT — UCEC

Explore this scatter interactively →