Positive regulation of non-canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of non-canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEATR5B, SPIN2A, and HIPK4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HEATR5B grouped by Positive regulation of non-canonical NF-kappaB signal transduction-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HEATR5B →	+0.677	+0.312	.004	.006	3	4
OESOPHAGUS	SPIN2A →	+0.406	+0.141	.002	.001	3	4
BLOOD_Myeloma	HIPK4 →	+0.063	+0.260	.003	<.001	3	3
BREAST	TSEN54 →	+1.032	+0.178	.005	<.001	3	3
BREAST	RECQL5 →	+0.847	+0.187	.003	<.001	3	3
BREAST	MKS1 →	+0.733	+0.148	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HEATR5B by Positive regulation of non-canonical NF-kappaB signal transduction activity — BLOOD_Lymphoma

Explore this box plot interactively →