Positive regulation of p38MAPK cascade

Across TCGA cell cohorts, RNA activity of the Positive regulation of p38MAPK cascade pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARD8, DNAJC8, and PRKD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CARD8 grouped by Positive regulation of p38MAPK cascade-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CARD8 →	-0.662	-0.731	<.001	.002	3	4
CNS	DNAJC8 →	-0.493	-0.608	.001	.005	3	4
LUNG_NSCLC_LUAD	PRKD2 →	-0.766	-0.276	<.001	.008	3	4
CNS	PLEKHM2 →	-0.671	-0.610	.004	.004	3	3
CNS	PARP9 →	-1.591	-0.610	.001	.008	3	3
CNS	KLF15 →	+0.947	+0.506	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CARD8 by Positive regulation of p38MAPK cascade activity — CNS

Explore this box plot interactively →