Regulation of synaptic vesicle endocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of synaptic vesicle endocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KANK2, LMOD1_S85, and PPP1R12B, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic vesicle endocytosis activity versus KANK2 in BRCA (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KANK2 →	+0.481	+0.044	.001	<.001	3	9
CCRCC	LMOD1_S85 →	+0.921	+0.051	<.001	<.001	3	8
CCRCC	PPP1R12B →	+0.617	+0.051	<.001	<.001	3	8
CCRCC	SORBS2 →	+0.475	+0.051	<.001	<.001	3	7
CCRCC	SORBS3 →	+0.309	+0.029	<.001	<.001	3	7
PDAC	SYNPO2_S363 →	+0.973	+0.049	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900242 vs KANK2 — BRCA

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