Positive regulation of amyloid-beta clearance

Across TCGA patient cohorts, RNA activity of the Positive regulation of amyloid-beta clearance pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3A1, SNRPD2, and DDX23, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of amyloid-beta clearance activity versus SF3A1 in OV (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SF3A1 →	-0.163	-0.074	.006	<.001	3	8
LSCC	SNRPD2 →	-0.199	-0.058	<.001	<.001	3	8
LSCC	DDX23 →	-0.302	-0.090	<.001	<.001	3	8
LSCC	SEH1L →	-0.179	-0.093	<.001	<.001	3	7
GBM	STAB1 →	+0.510	+0.060	.002	.001	3	7
LSCC	CTSZ →	+0.358	+0.094	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900223 vs SF3A1 — OV

Explore this scatter interactively →