Positive regulation of amyloid-beta clearance

Across TCGA patient cohorts, RNA activity of the Positive regulation of amyloid-beta clearance pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCN4, LY96, and LINC02461, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of amyloid-beta clearance activity versus CCN4 in OV (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CCN4 →	+1.675	+0.224	<.001	<.001	3	5
COAD	LY96 →	+0.826	+0.191	<.001	<.001	3	5
OV	LINC02461 →	+0.483	+0.145	.002	.001	3	5
COAD	LILRA1 →	+0.365	+0.174	<.001	<.001	3	4
OV	SFRP4 →	+1.598	+0.173	<.001	<.001	3	4
OV	ECM2 →	+0.853	+0.131	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900223 vs CCN4 — OV

Explore this scatter interactively →