Positive regulation of amyloid-beta clearance

Across TCGA cell cohorts, RNA activity of the Positive regulation of amyloid-beta clearance pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFAND2A, COQ3, and TSTD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZFAND2A grouped by Positive regulation of amyloid-beta clearance-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZFAND2A →	+0.685	+1.087	.004	<.001	3	5
BONE	COQ3 →	-0.705	-0.714	.003	.008	3	4
LUNG_SCLC	TSTD2 →	+1.063	+1.197	<.001	.002	3	4
LARGE_INTESTINE	BIN3 →	-0.804	-1.077	.001	.006	3	4
CNS	HSPB9 →	+0.146	+1.190	.002	<.001	3	3
PANCREAS	ZNF557 →	+0.420	+0.946	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZFAND2A by Positive regulation of amyloid-beta clearance activity — SKIN

Explore this box plot interactively →