Positive regulation of amyloid-beta clearance

Across TCGA cell cohorts, RNA activity of the Positive regulation of amyloid-beta clearance pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HBB, PDS5B, and ZNF75A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HBB grouped by Positive regulation of amyloid-beta clearance-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HBB →	+0.258	+1.485	<.001	<.001	3	3
SKIN	PDS5B →	+0.347	+0.320	.004	.006	3	3
BLOOD_Leukemia	ZNF75A →	+0.244	+1.458	<.001	.001	3	3
OVARY	FABP12 →	-0.220	-0.264	.003	.001	3	3
BONE	YY1 →	+0.375	+0.345	.007	.008	3	3
SKIN	CORO2A →	-0.201	-0.403	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HBB by Positive regulation of amyloid-beta clearance activity — BLOOD_Leukemia

Explore this box plot interactively →