Regulation of amyloid-beta clearance

Across TCGA patient cohorts, RNA activity of the Regulation of amyloid-beta clearance pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHF5A, FGD5_S744, and STAB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amyloid-beta clearance activity versus PHF5A in BRCA (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PHF5A →	-0.218	-0.035	<.001	.008	2	7
LSCC	FGD5_S744 →	+0.403	+0.070	.002	<.001	3	6
UCEC	STAB1 →	+0.322	+0.131	.002	<.001	3	5
BRCA	DNAJC9 →	-0.319	-0.044	.001	<.001	3	5
BRCA	ISLR →	+0.534	+0.033	<.001	.004	3	5
BRCA	LRP1 →	+0.339	+0.036	.009	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900221 vs PHF5A — BRCA

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