Regulation of amyloid-beta clearance

Across TCGA cell cohorts, RNA activity of the Regulation of amyloid-beta clearance pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMDHD2, TENT5A, and MYO1D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amyloid-beta clearance activity versus AMDHD2 in LIVER (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	AMDHD2 →	-0.886	-0.333	.006	.006	3	4
LUNG_NSCLC_LUAD	TENT5A →	+1.539	+1.010	<.001	<.001	3	4
LIVER	MYO1D →	+2.925	+0.397	.003	.002	3	3
OESOPHAGUS	PANK3 →	-0.747	-1.003	.004	.003	3	3
BLOOD_Leukemia	TRIM45 →	+0.887	+0.987	<.001	.001	2	4
BLOOD_Leukemia	USP54 →	+0.739	+0.952	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900221 vs AMDHD2 — LIVER

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