"Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA patient cohorts, RNA activity of the "Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WASHC4, RPL5, and CCDC86_S18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity versus WASHC4 in GBM (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WASHC4 →	-0.177	-0.060	<.001	<.001	3	5
LSCC	RPL5 →	-0.151	-0.052	<.001	<.001	3	5
LUAD	CCDC86_S18 →	-0.259	-0.041	.001	.004	3	5
COAD	DENR_S73 →	-0.475	-0.032	<.001	<.001	3	4
COAD	DIAPH1 →	-0.203	-0.032	<.001	<.001	3	4
COAD	HSPA8 →	-0.098	-0.021	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900152 vs WASHC4 — GBM

Explore this scatter interactively →