"Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA pan-cancer cohorts, RNA activity of the "Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher "Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and READ, show the opposite pattern, with higher activity associated with better survival.

HNSC, LGG, and READ are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.653	0.502	<.001	113	view →
LGG	DFS	Median	All	0.613	0.817	<.001	54	view →
READ	OS	Median	II,III,IV	0.879	0.405	<.001	47	view →
KICH	OS	Tertile	All	0.594	0.958	.002	45	view →
UVM	DFS	Tertile	II,III,IV	0.314	0.724	.005	32	view →
LUAD	DFS	Tertile	IV	0.310	0.896	.006	30	view →
DLBC	DFS	Tertile	All	0.527	0.939	.003	20	view →
KIRP	DFS	Quartile	All	0.567	0.808	.007	18	view →
UCEC	DFS	Quartile	All	0.599	0.728	.003	16	view →
PCPG	OS	Median	All	0.814	1.000	.007	15	view →
ACC	DFS	Tertile	All	0.382	0.619	.036	13	view →
CESC	DFS	Quartile	III,IV	0.587	0.816	.026	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:1900152–HNSC (DFS)

Open the HNSC breakdown →