"Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA pan-cancer cohorts, RNA activity of the "Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway differs between tumor and matched normal tissue in 9 of the 18 cancer types tested.

The strongest signal is observed in kidney chromophobe (KICH), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and KIRC, show the opposite pattern, with lower activity in tumor tissue.

KICH, KIRC, and COAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KICH	Female	All	−0.074	<.001	10	view →
KIRC	Male	IV	−0.042	<.001	10	view →
COAD	All	All	+0.027	<.001	9	view →
THCA	All	II,III,IV	−0.037	<.001	7	view →
LUSC	Male	All	+0.043	<.001	5	view →
CHOL	All	All	+0.057	.019	3	view →
KIRP	Male	All	−0.036	<.001	3	view →
LUAD	All	All	+0.028	.003	2	view →
BRCA	All	III,IV	−0.022	.034	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 9 strongest of 9 lineages.

GO:1900152–KICH

Open the KICH breakdown →