"Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA patient cohorts, RNA activity of the "Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARPBP, IGF2BP1, and FANCB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity versus PARPBP in LUAD (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PARPBP →	+0.507	+0.128	.007	.009	3	6
HNSC	IGF2BP1 →	+2.022	+0.245	<.001	<.001	3	5
LSCC	FANCB →	+0.554	+0.119	.002	.002	3	5
LSCC	PRKCH →	-0.375	-0.217	<.001	<.001	3	5
UCEC	CAST →	-0.448	-0.191	<.001	<.001	3	5
HNSC	TRIP13 →	+0.751	+0.247	.009	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900152 vs PARPBP — LUAD

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