"Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR152, ALYREF, and EZH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPR152 grouped by "Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GPR152 →	+0.230	+0.152	.005	<.001	3	5
LUNG_NSCLC_LUSC	ALYREF →	-0.348	-0.101	.003	.004	3	4
UPPER_AERODIGESTIVE_TRACT	EZH1 →	-0.201	-0.099	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	UTP4 →	-0.319	-0.096	.003	.005	3	4
SKIN	GCSAML →	+0.179	+0.114	.002	<.001	3	4
LUNG_SCLC	RBMS3 →	+0.269	+0.164	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPR152 by "Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity — LUNG_SCLC

Explore this box plot interactively →