"Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAIP1, TOB1, and C5orf51, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity versus PAIP1 in LUNG_SCLC (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PAIP1 →	+1.266	+0.158	.001	<.001	3	13
OESOPHAGUS	TOB1 →	+1.478	+0.126	.001	.001	3	12
OVARY	C5orf51 →	+0.724	+0.087	<.001	.001	3	12
BLOOD_Lymphoma	PHIP →	+1.020	+0.075	<.001	<.001	3	11
BLOOD_Leukemia	PSEN1 →	+0.610	+0.068	<.001	<.001	3	11
OVARY	ZBTB6 →	+0.925	+0.151	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900152 vs PAIP1 — LUNG_SCLC

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