"Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRSF7, PPP1CC, and HNRNPM, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity versus SRSF7 in LIVER (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SRSF7 →	+0.706	+0.324	.009	<.001	3	8
PANCREAS	PPP1CC →	+0.714	+0.209	.002	<.001	3	7
OVARY	HNRNPM →	+0.871	+0.232	<.001	<.001	3	7
OVARY	RTN4IP1 →	+1.179	+0.213	<.001	<.001	3	7
LARGE_INTESTINE	METTL21A →	+1.074	+0.153	<.001	.006	3	7
OVARY	KHSRP →	+1.248	+0.317	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900152 vs SRSF7 — LIVER

Explore this scatter interactively →