Regulation of defense response to fungus

Across TCGA patient cohorts, RNA activity of the Regulation of defense response to fungus pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP7, FERMT2, and PIP4K2B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of defense response to fungus activity versus FKBP7 in UCEC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FKBP7 →	-0.529	-0.061	<.001	<.001	3	6
UCEC	FERMT2 →	-0.425	-0.049	.003	.001	3	6
GBM	PIP4K2B →	-0.221	-0.062	.009	.009	3	6
OV	CENPV →	-0.720	-0.065	<.001	<.001	3	6
UCEC	NES →	-0.448	-0.056	<.001	<.001	3	6
GBM	UPP1 →	+0.610	+0.055	.002	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900150 vs FKBP7 — UCEC

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