Positive regulation of execution phase of apoptosis

Across TCGA patient cohorts, RNA activity of the Positive regulation of execution phase of apoptosis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C7, MSRB3, and GATA6-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of execution phase of apoptosis activity versus C7 in CCRCC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	C7 →	+1.982	+0.702	<.001	.002	3	5
CCRCC	MSRB3 →	+0.681	+0.563	<.001	<.001	3	5
PDAC	GATA6-AS1 →	+0.851	+0.862	<.001	<.001	3	5
COAD	DNM3OS →	+0.819	+0.783	<.001	<.001	3	5
GBM	ADGRD1 →	+0.347	+0.544	.001	<.001	3	5
UCEC	LINC00702 →	+0.692	+0.723	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900119 vs C7 — CCRCC

Explore this scatter interactively →