Positive regulation of execution phase of apoptosis

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of execution phase of apoptosis pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Positive regulation of execution phase of apoptosis pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and LUAD, show the opposite pattern, with higher activity associated with better survival.

UVM, ACC, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	II,III,IV	1.000	0.622	<.001	128	view →
ACC	DFS	Tertile	All	0.312	0.778	<.001	120	view →
MESO	OS	Median	All	0.250	0.517	<.001	96	view →
KIRC	OS	Quartile	All	0.565	0.740	<.001	81	view →
LUAD	OS	Quartile	II,III,IV	0.616	0.292	.002	47	view →
LGG	OS	Quartile	All	0.367	0.579	<.001	28	view →
COAD	DFS	Tertile	IV	0.321	0.574	.014	27	view →
SKCM	DFS	Median	IV	0.763	0.187	.006	25	view →
READ	OS	Median	III,IV	0.812	0.943	.015	24	view →
SCLC	OS	Quartile	II,III,IV	0.143	0.553	.004	22	view →
LUSC	DFS	Quartile	All	0.296	0.450	.010	15	view →
BRCA	OS	Quartile	III,IV	0.913	0.740	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:1900119–UVM (OS)

Open the UVM breakdown →