Positive regulation of endoplasmic reticulum unfolded protein response

Across TCGA patient cohorts, RNA activity of the Positive regulation of endoplasmic reticulum unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2L11, ERN1, and TBC1D12, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endoplasmic reticulum unfolded protein response activity versus BCL2L11 in UVM (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	BCL2L11 →	+1.078	+0.062	<.001	<.001	3	31
ACC	ERN1 →	+1.334	+0.039	<.001	<.001	2	32
DLBC	TBC1D12 →	+1.179	+0.087	<.001	<.001	3	30
UVM	CSGALNACT2 →	+1.437	+0.062	<.001	<.001	3	30
ACC	NUMB →	+0.894	+0.045	<.001	<.001	3	30
UVM	ASXL2 →	+1.060	+0.056	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900103 vs BCL2L11 — UVM

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