Positive regulation of endoplasmic reticulum unfolded protein response

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of endoplasmic reticulum unfolded protein response pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 13 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Positive regulation of endoplasmic reticulum unfolded protein response pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

HNSC, SKCM, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.495	0.211	<.001	104	view →
SKCM	DFS	Quartile	III,IV	0.808	0.550	<.001	50	view →
ACC	DFS	Tertile	All	0.155	0.668	.001	48	view →
ESCA	DFS	Quartile	III,IV	0.658	0.247	.012	45	view →
LGG	DFS	Median	All	0.312	0.492	<.001	41	view →
LUAD	DFS	Quartile	All	0.769	0.591	.002	38	view →
OV	DFS	Median	All	0.583	0.503	.007	26	view →
KIRC	DFS	Tertile	All	0.543	0.696	.005	18	view →
KIRP	DFS	Tertile	III,IV	0.204	0.719	.003	15	view →
TGCT	DFS	Tertile	All	0.871	0.711	.034	6	view →
SCLC	OS	Median	IV	0.228	0.639	.033	6	view →
BRCA	OS	Quartile	All	0.975	0.944	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:1900103–HNSC (OS)

Open the HNSC breakdown →