Positive regulation of endoplasmic reticulum unfolded protein response

Across TCGA cell cohorts, RNA activity of the Positive regulation of endoplasmic reticulum unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS27, TSPAN33, and FAM168B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endoplasmic reticulum unfolded protein response activity versus MRPS27 in PANCREAS (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MRPS27 →	-0.924	-0.361	<.001	<.001	3	4
PANCREAS	TSPAN33 →	-1.563	-0.341	<.001	.001	3	4
LUNG_SCLC	FAM168B →	-0.693	-0.308	.005	.002	3	4
STOMACH	ZBTB10 →	-1.581	-0.314	.002	.002	3	4
LUNG_NSCLC_LUAD	PIK3CD →	-0.933	-0.216	.001	<.001	3	4
LUNG_NSCLC_LUAD	ATP6V1G2 →	-0.510	-0.243	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900103 vs MRPS27 — PANCREAS

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