Regulation of plasma cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of plasma cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD4, PLEKHO2, and SEPTIN1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of plasma cell differentiation activity versus CD4 in GBM (Pearson r = -0.68).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD4 →	-0.643	-0.124	<.001	<.001	3	9
BRCA	PLEKHO2 →	-0.419	-0.116	<.001	<.001	3	9
GBM	SEPTIN1 →	-1.083	-0.118	<.001	.003	3	9
OV	CD2 →	-1.377	-0.151	<.001	<.001	3	9
GBM	CRLF3 →	-0.359	-0.110	<.001	<.001	3	8
GBM	DOK2 →	-0.770	-0.124	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900098 vs CD4 — GBM

Explore this scatter interactively →