Regulation of plasma cell differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of plasma cell differentiation pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher Regulation of plasma cell differentiation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUSC and BLCA, show the opposite pattern, with higher activity associated with better survival.

READ, LUSC, and STAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	III,IV	0.409	0.888	.004	39	view →
LUSC	OS	Tertile	II,III,IV	0.714	0.502	.004	36	view →
STAD	DFS	Median	II,III,IV	0.337	0.668	.003	33	view →
BLCA	OS	Tertile	All	0.709	0.571	.009	22	view →
THYM	DFS	Quartile	II,III,IV	1.000	0.540	.007	20	view →
LGG	OS	Quartile	All	0.945	0.826	<.001	19	view →
UCS	DFS	Tertile	II,III,IV	0.151	0.588	.005	18	view →
COAD	OS	Median	IV	0.339	0.833	.008	18	view →
LIHC	DFS	Quartile	All	0.435	0.659	.004	14	view →
UVM	OS	Quartile	All	0.808	0.432	.006	11	view →
DLBC	DFS	Median	III,IV	0.383	0.984	.043	9	view →
ESCA	OS	Median	All	1.000	0.659	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:1900098–READ (OS)

Open the READ breakdown →