Regulation of plasma cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of plasma cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL6, PIBF1, and MGST3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of plasma cell differentiation activity versus BCL6 in HNSC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BCL6 →	+1.112	+0.697	<.001	.001	3	7
OV	PIBF1 →	-0.453	-0.392	.008	.009	3	4
GBM	MGST3 →	-0.178	-0.246	.008	.007	3	4
LUAD	KANK4 →	-0.771	-0.489	.001	.001	3	3
BRCA	SLC30A4 →	-0.553	-0.408	<.001	<.001	3	3
BRCA	CEP85L →	-0.548	-0.386	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900098 vs BCL6 — HNSC

Explore this scatter interactively →