Regulation of plasma cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of plasma cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCL6_S333, BCL6_S457, and BCL6_S343, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of plasma cell differentiation activity versus BCL6_S333 in UCEC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BCL6_S333 →	+0.597	+0.320	<.001	<.001	3	7
LUAD	BCL6_S457 →	+1.110	+0.558	<.001	<.001	3	7
UCEC	BCL6_S343 →	+0.868	+0.486	<.001	<.001	2	7
BRCA	BCL6_S404 →	+0.998	+0.623	<.001	.004	1	5
GBM	AKAP11_S1611 →	+1.121	+0.344	<.001	<.001	3	3
GBM	BORCS6_T196 →	+0.527	+0.327	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900098 vs BCL6_S333 — UCEC

Explore this scatter interactively →