Positive regulation of G1/S transition of mitotic cell cycle

Across TCGA patient cohorts, RNA activity of the Positive regulation of G1/S transition of mitotic cell cycle pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC4, UBE2T, and H1-10_S31, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of G1/S transition of mitotic cell cycle activity versus SMC4 in BRCA (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMC4 →	+0.689	+0.043	<.001	<.001	3	8
GBM	UBE2T →	+0.512	+0.043	.005	.008	3	7
LUAD	H1-10_S31 →	+0.725	+0.040	<.001	<.001	3	7
OV	NUF2 →	+0.708	+0.046	<.001	<.001	3	7
LUAD	CIP2A →	+0.521	+0.042	<.001	<.001	3	7
PDAC	TPX2_S486 →	+1.246	+0.058	<.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900087 vs SMC4 — BRCA

Explore this scatter interactively →