Positive regulation of G1/S transition of mitotic cell cycle

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of G1/S transition of mitotic cell cycle pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as THCA and LUSC, show the opposite pattern, with lower activity in tumor tissue.

HNSC, KIRC, and KIRP show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
HNSC	Female	All	+0.032	<.001	12	view →
KIRC	All	All	+0.029	<.001	11	view →
KIRP	All	All	+0.039	<.001	9	view →
THCA	All	II,III,IV	−0.024	.004	7	view →
LUSC	Male	All	−0.027	<.001	6	view →
LUAD	Female	II,III,IV	−0.048	<.001	5	view →
LIHC	All	All	−0.021	<.001	5	view →
READ	All	III,IV	+0.034	.019	2	view →
BRCA	Female	All	−0.009	.036	2	view →
COAD	Female	III,IV	+0.022	.008	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:1900087–HNSC

Open the HNSC breakdown →